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What is Anti- GAL antibody

Anti-Gal is the most common natural antibody found in humans, accounting for about 1% of all immunoglobulins. Anti-Gal is a natural product that is also found in apes as well as Old World monkeys. You can know more about Anti- GAL antibodies via

Development of α‐Gal–Antibody Conjugates to Increase Immune Response by  Recruiting Natural Antibodies - Sianturi - 2019 - Angewandte Chemie  International Edition - Wiley Online Library

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Anti-Gal ligand is a carbohydrate antigen known as the ‘a-gal epitope,’ which has the structure Gala1-3Galb1-4GlcNAc-R. The epitope of a-gal is found as an important carbohydrate antigen found in prosimians, non-primate mammals, and New World monkeys. 

Anti-Gal may be involved in the development of several immune-mediated pathogens. The anti-Gal IgE that is produced by some people causes allergic reactions to meat, as well as to the monoclonal therapeutic antibody cetuximab. 

A-Gal epitopes created from Trypanosoma cruzi react with anti-Gal to trigger ‘autoimmune similar’ inflammatory reactions to Chagas”‘. The anti-Gal IgM and IgG further aid in the rejection of xenografts that express epitopes from the a-gal. 

Due to its abundance, it is possible to exploit anti-Gal to treat various diseases. It enhances the immunogenicity of the microbial vaccines (e.g. influenza vaccine) which contain a-gal epitopes by making them targets for efficient uptake by cells that express antigens.

Anti-Gal binding to epitopes of a-gal in tumor cells makes them more susceptible to being absorbed by cells that express antigens. The speedy healing of wounds is accomplished by the application of nanoparticles of a-gal that bind anti-Gal activate complement and stimulate macrophages to trigger tissue regeneration.